Abstract #4538

Diffusion Tensor Imaging Detects Cross-Sectional and Longitudinal Brain Changes in Type 2 Diabetes Mellitus

Bhaswati Roy¹, Sarah E Choi², Milena Lai³, Luke Ehlert³, Rashmi Mullur⁴, Matthew J. Freeby⁴, and Rajesh Kumar^3,5,6,7

¹University of California at Los Angeles, LOS ANGELES, CA, United States, ²UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ³Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Radiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States

Patients with Type 2 diabetes mellitus (T2DM) show brain tissue changes in mood and cognitive control sites, functions that are deficient in the condition. However, the nature and extent of brain injury in T2DM, and their progression with time along with functional deficits are unclear. Using diffusion tensor imaging based MD procedures, we showed wide-spread chronic tissue changes in T2DM subjects and their continued progression after 6 months follow-up in areas involve in mood and cognitive regulatory functions. These findings may have resulted from underlying metabolic dysfunction associated with the condition.

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