Abstract #4539

Preliminary Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer’s Disease

Maurizio Bergamino¹, Ashley Nespodzany¹, Leslie C Baxter^1,2, Anna Burke³, Richard Caselli², Marwan N Sabbagh⁴, Ryan R Walsh⁵, and Ashley M Stokes¹

¹Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²Mayo Clinic Arizona, Phoenix, AZ, United States, ³Department of Neuropsychiatry, Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, ⁵The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States

The objective of this study was to assess complementary metrics from voxel-based morphometry (VBM) and intravoxel incoherent motion diffusion-weighted images (IVIM-DWI) MRI methods in aging populations. Using voxel-based analysis, grey matter (GM) and white matter (WM) differences were analyzed across Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively normal (HC) individuals. IVIM-DWI demonstrated early significant differences between MCI and HC groups, while VBM did not. In addition, voxel-based correlations between neuroimaging metrics and cognitive assessments were assessed in the cognitively impaired groups (AD and MCI).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.