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Abstract #4539

Preliminary Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI (IVIM-DWI) Metrics in Alzheimer’s Disease

Maurizio Bergamino1, Ashley Nespodzany1, Leslie C Baxter1,2, Anna Burke3, Richard Caselli2, Marwan N Sabbagh4, Ryan R Walsh5, and Ashley M Stokes1
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic Arizona, Phoenix, AZ, United States, 3Department of Neuropsychiatry, Barrow Neurological Institute, Phoenix, AZ, United States, 4Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 5The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States

The objective of this study was to assess complementary metrics from voxel-based morphometry (VBM) and intravoxel incoherent motion diffusion-weighted images (IVIM-DWI) MRI methods in aging populations. Using voxel-based analysis, grey matter (GM) and white matter (WM) differences were analyzed across Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively normal (HC) individuals. IVIM-DWI demonstrated early significant differences between MCI and HC groups, while VBM did not. In addition, voxel-based correlations between neuroimaging metrics and cognitive assessments were assessed in the cognitively impaired groups (AD and MCI).

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