Abstract #4546

Ultra-high b-value Diffusion MRI for Evaluation of Single Amyloid Precursor Protein Knock-in Mouse Model of Alzheimer’s Disease

Jin Gao^1,2, Zachery Morrissey³, Alex Leow³, Orly Lazarov⁴, Danilo Erricolo¹, Richard Magin⁵, and Weiguo Li^2,5

¹Electrical and Computer Engineering, University of Illinois at Chicago, Chicago, IL, United States, ²Research Resources Center, University of Illinois at Chicago, Chicago, IL, United States, ³Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, United States, ⁵Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Alzheimer’s disease (AD) has a tremendous impact in terms of social and economic cost. White matter damage in the progression of AD and the associated cognitive symptoms and pathophysiology are of crucial interest. Diffusion MRI offers unique insights into the pathophysiology of AD in vivo. This feasibility study aims to assess and visualize the white matter changes using an ultrahigh b-value diffusion MRI.

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