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Abstract #4566

Assessment with Partial Peripheral Nerve Transection with Diffusion MRI

Isaac Vicente Manzanera Esteve1, Angel F Farinas1, Alonda C Pollins1, Wesley P Thayer1, Mark Does1, and Richard Dortch1
1VUIIS, Vanderbilt University Medical Center, Nashville, TN, United States

High-resolution DTI of ex vivo rat sciatic nerve yields viable biomarkers of peripheral nerve recovery following partial transection and surgical repair. FA values decreased with increasing cut depth at 4 weeks. By week 12, the three partial cuts showed elongated FA distributions, most likely representing regions with regenerated (high FA values) and degenerated axons (low FA values). FA finding are influenced by pathological features that affect diffusion both perpendicular and parallel to the axons.

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