Abstract #4567

Characterisation of placentome function using combined diffusion-relaxometry MRI and flow anisotropy

Dimitra Flouri^1,2, Jack RT Darby³, Stacey L Holman³, Sunthara R Perumal⁴, Anna L David^5,6, Andrew Melbourne^1,2, and Janna L Morrison³

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ³Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, ⁴Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁵Institute for Women's Health, University College London, London, United Kingdom, ⁶NIHR University College London Hospitals Biomedical Research Center, London, United Kingdom

Abnormal development of the placenta is postulated as the root cause of preeclampsia and fetal growth restriction. Diffusion-Weighted imaging techniques are considered to give additional placental information. Animal models have been important in invasive validation studies for MRI measurements, as they allow for controlled experiments and analysis of multiple time-points during pregnancy. This study characterises diffusion and perfusion properties of the placenta such as the apparent diffusion coefficient, T2 measurements, fractional anisotropy and perfusion fraction derived from intravoxel incoherent motion analysis on sheep placental tissue in order to validate new imaging markers of placental function.

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