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Abstract #4567

Characterisation of placentome function using combined diffusion-relaxometry MRI and flow anisotropy  

Dimitra Flouri1,2, Jack RT Darby3, Stacey L Holman3, Sunthara R Perumal4, Anna L David5,6, Andrew Melbourne1,2, and Janna L Morrison3
1School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 3Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, 4Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, 5Institute for Women's Health, University College London, London, United Kingdom, 6NIHR University College London Hospitals Biomedical Research Center, London, United Kingdom

Abnormal development of the placenta is postulated as the root cause of preeclampsia and fetal growth restriction. Diffusion-Weighted imaging techniques are considered to give additional placental information. Animal models have been important in invasive validation studies for MRI measurements, as they allow for controlled experiments and analysis of multiple time-points during pregnancy. This study characterises diffusion and perfusion properties of the placenta such as the apparent diffusion coefficient, T2 measurements, fractional anisotropy and perfusion fraction derived from intravoxel incoherent motion analysis on sheep placental tissue in order to validate new imaging markers of placental function.

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