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Abstract #4579

White matter development after prenatal chemotherapy exposure: a diffusion MRI fixel-based analysis.

Jeroen Blommaert1, Ahmed Radwan2, Charlotte Sleurs1, Ron Peeters2,3, Stefan Sunaert2,3, An-Sofie Gorissen1, Kristel Van Calsteren4,5, Frédéric Amant1,6,7, and Sabine Deprez2
1Oncology, KU Leuven, Leuven, Belgium, 2Imaging & Pathology, KU Leuven, Leuven, Belgium, 3Radiology, University Hospitals Leuven, Leuven, Belgium, 4Development and regeneration, KU Leuven, Leuven, Belgium, 5Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium, 6Gynecological Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, Netherlands, 7Gynaecological oncology, Amsterdam university medical centers, Amsterdam, Netherlands

Currently, data are scarce on the long-term outcome of prenatal exposure to cancer treatment. In this preliminary analysis, we investigated white matter development in 9-year-old children who were prenatally exposed to chemotherapy, using multi-shell diffusion MRI and fixel-based analysis. We found indications of lower within-voxel (reflected by Fibre Density), macroscopic (reflected by Fibre Cross-section) and total (reflected by Fibre Density and Cross-section) intra-axonal volume of the splenium, isthmus and tapetal fibres of the corpus callosum in children with prenatal chemotherapy exposure compared to controls. This suggests prenatal chemotherapy exposure to potentially impact white matter development.

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