Abstract #4580

Neurochemical Correlates of Brain Abnormalities in Prenatal Alcohol Exposure: Interim Analysis

Jeffry R. Alger^1,2,3, Joseph O'Neill⁴, Lisa Kilpatrick⁴, Katherine L. Narr¹, Guldamla Kalender⁴, Ronald Ly⁴, Shantanu H. Joshi¹, Sandy Loo⁴, Mary J. O'Connor⁴, and Jennifer G. Levitt⁴

¹Neurology, University of California, Los Angeles, Los Angeles, CA, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, ⁴Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States

Multimodal MR neuroimaging was used to identify brain differences between attention deficit hyperactivity disorder (ADHD) associated with prenatal alcohol exposure (PAE) (ADHD+PAE), ADHD not associated PAE (ADHD-PAE) and normally-developing controls in an study of children aged 8-12 years. This is an interim report of findings obtained from an ongoing study after successful imaging of 73 subjects. Statistically-significant lateralized brain differences were identified in frontal white matter and gray matter. The findings provide preliminary support for the hypothesis that an objective diagnostic neuroimaging-based classifier can be developed.

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