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Abstract #4584

Altered Cortical Folding Depth in Fetuses with Down Syndrome

HyukJin Yun1, Juan David Perez1, Neel Madan2, Rie Kitano3, Shizuko Akiyama4, Diana W. Bianchi5, P. Ellen Grant1, Tomo Tarui4, and Kiho Im1
1Newborn Medicine, Boston Children's Hospital, Boston, MA, United States, 2Radiology, Tufts Medical Center, Boston, MA, United States, 3Obstetrics and Gynecology, Long Island Jewish Medical Center, New Hyde Park, NY, United States, 4Mother Infant Research Institute, Tufts Medical Center, Boston, MA, United States, 5Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, United States

Analyzing fetal brains with Down syndrome is an interesting are because genetic factors affect brain development in early fetal stages. In addition to cortical volumetric and areal measures used in our previous studies, cortical folding in the fetal brain would be an important marker of altered neurodevelopment due to Down syndrome. Thus, we calculated sulcal depth to quantify cortical folding and compared sulcal depth between Down syndrome and typically developing fetuses. Down syndrome fetuses showed significantly altered sulcal depth compared to typically developing peers in the regions related to decreased neurogenesis in early fetal life.

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