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Abstract #4592

Investigation of Longitudinal Nonhuman Primate White Matter Maturation using Quantitative R1 Relaxometry 

Douglas C Dean1,2,3, Jason F Moody2, Steve R Kecskemeti3, Nakul Aggarwal4, Jonathan A Oler4, Andrew L Alexander2,3,4, and Ned Kalin4
1Pediatrics, University of Wisconsin–Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin–Madison, Madison, WI, United States, 3Waisman Center, University of Wisconsin–Madison, Madison, WI, United States, 4Psychiatry, University of Wisconsin–Madison, Madison, WI, United States

Quantitative relaxometry affords a unique opportunity to map dynamic patterns of white matter development. Nonhuman primates offer a valuable model for investigating neurodevelopment, however, NHP studies utilizing relaxometry based approaches have been limited. Here, we utilize R1 relaxometry to map maturation in 35 rhesus macaques scanned across 5 timepoints during the first year of life. R1 is observed to rapidly increase during this period, with average and individual patterns exhibiting a logarithmic-like trajectory. Results highlight the onset of myelin during this period of development and demonstrate relaxometry to be a promising approach for characterizing patterns of early brain development.

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