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Abstract #4593

Improved quantitative accuracy using high-resolution DTI guided QSM to profile myelin maturation in pediatric brains

Lijia Zhang1, Chris Petty1, and Allen Song1
1Duke University Brain Imaging and Analysis Center, Durham, NC, United States

Quantitative susceptibility mapping (QSM) has the potential to help access brain development, in particular, the magnetic susceptibility changes during the myelination processes in the white matter. However, the quantitative accuracy of QSM is limited by its angle dependency to the fiber orientation. In this study, we propose a method utilizing ultra-high resolution diffusion tensor imaging (DTI) to delineate the major fiber bundles (i.e. corpus callosal fibers), followed by tract-based QSM, to largely remove the angle dependence and accurately quantify the magnetic susceptibility changes during brain development.

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