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Abstract #4595

White Matter Left-lateralization from Birth through Childhood Revealed by Tract-based Spatial Statistics with Dynamic Age-specific Templates

Xianjun Li1, Yuli Zhang1, Mengxuan Li1, Miaomiao Wang1, Congcong Liu1, Chao Jin1, Xiaocheng Wei1, and Jian Yang1
1Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

Human brain exhibits structural and functional asymmetries. How the left-lateralization in white matter changes with age from newborns through childhood is not fully investigated. In this work, development of the left-lateralization from birth to 13 years is revealed by using tract-based spatial statistics with dynamic age-specific brain templates. Structural left-lateralization with larger fractional anisotropy in motor-related and language-related white matter is already present in newborns. The involvement of corticospinal tract, superior longitudinal fasciculus and uncinate fasciculus into regions with left-lateralization appears at different age. This may be associated with the development of fine motor and language during the early childhood.

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