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Abstract #4597

Subcortical abnormalities in adolescents with first-episode drug-naïve major depressive disorder

Ruohan Feng1, Lihua Zhuo1, Xinyue Hu2, Yingxue Gao2, Lianqing Zhang2, Yang Li3, Xinyu Hu2, Shi Tang2, Ming Zhou1, Guoping Huang3, and Xiaoqi Huang2
1Department of Radiology, the third hospital of Mianyang, Mianyang, China, Mianyang, China, 2Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China, 3Department of Psychiatry, the third hospital of Mianyang, Mianyang, China, Mianyang, China

We analysis subcortical nucleus volume in 57 adolescents aged 13-18: 35 with MDD and 22 healthy controls (HC). Compared to HCs, the MDD group showed reduction in volume of the HATA nuclei of the left hippocampus and the subiculum nuclei of the right hippocampus, and increased volume in the LD、MDI、 MDm of the left thalamus and in the MV(Re) of the right thalamus. There were no significant difference in amygdala subregion between the MDD group and the HC group. We propose that these subregions will contribute to the affective and cognitive abnormities in adolescents with MDD.

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