Abstract #4597

Subcortical abnormalities in adolescents with first-episode drug-naïve major depressive disorder

Ruohan Feng¹, Lihua Zhuo¹, Xinyue Hu², Yingxue Gao², Lianqing Zhang², Yang Li³, Xinyu Hu², Shi Tang², Ming Zhou¹, Guoping Huang³, and Xiaoqi Huang²

¹Department of Radiology, the third hospital of Mianyang, Mianyang, China, Mianyang, China, ²Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China, ³Department of Psychiatry, the third hospital of Mianyang, Mianyang, China, Mianyang, China

We analysis subcortical nucleus volume in 57 adolescents aged 13-18: 35 with MDD and 22 healthy controls (HC). Compared to HCs, the MDD group showed reduction in volume of the HATA nuclei of the left hippocampus and the subiculum nuclei of the right hippocampus, and increased volume in the LD、MDI、 MDm of the left thalamus and in the MV(Re) of the right thalamus. There were no significant difference in amygdala subregion between the MDD group and the HC group. We propose that these subregions will contribute to the affective and cognitive abnormities in adolescents with MDD.

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