Abstract #4608

Wide-spread Reduced Cerebral Blood Flow in Patients with Right Ventricle Compared to Left Ventricle Single Ventricle Heart Disease

Rajesh Kumar^1,2,3,4, Bhaswati Roy¹, Xingfeng Shao⁵, Nancy J. Halnon⁶, Alan B. Lewis⁷, Mary A. Woo⁸, Danny JJ Wang^5,9, and Nancy A. Pike⁸

¹Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²Radiology, University of California at Los Angeles, Los Angeles, CA, United States, ³Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Neurology, University of Southern California, Los Angeles, CA, United States, ⁶Division of Pediatric Cardiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Division of Pediatric Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, ⁸UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ⁹Radiology, University of Southern California, Los Angeles, CA, United States

Single ventricle heart disease (SVHD) presents with either a dominant single right ventricle (RV) or left ventricle (LV). Individuals with RV dominant SVHD show worse outcomes, including worse cognition and quality of life, which may result from decreased cardiac output due to differences in ventricular size, shape, and function or other structural related sequela, contributing to regional cerebral blood flow (CBF) changes. We examined CBF changes between RV and LV over controls, and found more wide-spread changes in RV over LV. These findings indicate that worse outcomes in RV SVHD may result from compromised CBF over LV SVHD.

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