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Abstract #4607

Brain oxygen extraction fraction is associated with 10minute Apgar score and severity of hypoxic ischemic encephalopathy

Dengrong Jiang1, W. Christopher Golden2, Charlamaine Parkinson2, Li Pan3, Zixuan Lin1, Hanzhang Lu1, Aylin Tekes1, Frances Northington2, and Peiying Liu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3Siemens Healthineers, Baltimore, MD, United States

Hypoxic-ischemic-encephalopathy (HIE) is a leading cause of neonatal mortality and severe neurological impairment in childhood. Quantification of cerebral oxygen utilization in HIE neonates may provide valuable information to guide the treatment and predict clinical outcomes. Oxygen-extraction-fraction (OEF) is an important index of the brain’s oxygen utilization. In this work, we used a rapid, non-invasive MRI technique to measure the global OEF in HIE neonates, and examined the association of OEF with Apgar scores and the severity of HIE. We demonstrated that global OEF was associated with 10minute Apgar score. Global OEF also decreased with the severity of HIE.

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