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Abstract #4615

Mathematical Modeling of White Matter Development in Infant Rhesus Monkeys

Jason F. Moody1, Nakul Aggarwal2, Douglas C. Dean III1,3,4, Do Tromp2, Steve R. Kecskemeti4, Jonathan Oler2, Ned H. Kalin2, and Andrew L. Alexander1,2,3,4
1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States, 3Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, 4Waisman Center, University of Wisconsin-Madison, Madison, WI, United States

In this study, we use prototypical DTI metrics to assess longitudinal changes in white matter (WM) across the postnatal rhesus macaque brain, over the first year of life.

DTI trajectories extracted from 37 ROIs conform to a logarithmic model and illustrate an initial 10-week period of exceedingly rapid WM development, followed by a prominent plateau in alterations at approximately 6 months of age. K-means clustering of model parameters suggests distinct regional differences in WM maturation. Our analysis provides an early quantitative framework for attaining insights into healthy postnatal WM development, and eventually, establishing connections between WM deterioration and human psychopathology.

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