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Abstract #4614

Differences in Functional Integration and Segregation in CHD Neonates: Interactions with Sex

Vincent Jerome Schmithorst1, Jodie Votava-Smith2, and Ashok Panigrahy1
1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2Children's Hospital of Los Angeles, Los Angeles, CA, United States

Functional network topology was compared between neonates with congenital heart disease (CHD) and normal controls and sex-X-CHD interactions were investigated. Using a cost-independent analysis, CHD neonates displayed reduced segregation globally (modularity, transitivity) and nodally (clustering coefficient, participation coefficient) mainly in frontal and subcortical regions; no significant sex-X-CHD interactions were found. Using a cost-dependent analysis, CHD neonates displayed reduced integration and segregation globally (global efficiency, transitivity) and nodally (nodal efficiency, clustering coefficient) in frontal, temporal, and subcortical regions. Significant sex-X-CHD interactions (M>F) were found in similar regions. Results may support a neurophysiological basis for differential neurodevelopmental outcomes related to sex.

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