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Abstract #4625

DKI is a sensitive method for detect the white matter patho-morphological variations in neonates with mild white matter injury

Miaomiao Wang1, Mengxuan Li1, Xianjun Li1, Congcong Liu1, Yuli Zhang1, Fan Wu1, Xiaoyu Wang1, Cong Tian1, Peiyao Cheng1, XiaoCheng Wei2, and Jian Yang1
1The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, 2MR Research China, GE Healthcare, Beijing, China

White matter injury is common in neonates. The most common punctate white matter lesions (PWML) can disappear along with time and are easily missed diagnosis. Since DTI is not sensitive to detect the white matter (WM) microstructural changes in mild PWMLs, DKI may provide more details for capture the WM alterations. This study aims to investigate the utility of DKI in characterizing the WM microstructural variations following mild PWMLs. Our study found that diffusion kurtosis and two-compartment metrics are sensitive imaging markers for characterize the WM microstructural alterations of mild PWMLs, which is associated with reactive gliosis and axonal swelling.

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