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Abstract #4626

Simultaneous micro- and macrostructural assessment of normal brain development

Bénédicte Maréchal1,2,3, Gian Franco Piredda1,2,3, Tom Hilbert1,2,3, Clovis Tauber4, Jean-Philippe Cottier4, Jean-Philippe Thiran3, Tobias Kober1,2,3, and Baptiste Morel4,5
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4UMR 1253, iBrain, Université de Tours, Inserm, Tours, France, 5Pediatric Radiology Department, Clocheville Hospital, CHRU of Tours, Tours, France

MRI has become a routine diagnostic modality for evaluating normal structural and metabolic development of the brain in children. In this work, MP2RAGE sequence parameters and consecutive automated brain morphometry are optimized to overcome cohort-specific challenges due to wide variations in head size, head shape, and rapid changes in tissue contrast associated with myelination. Reference ranges for both volumetric and T1-relaxometry measures are built from a pediatric population with normal MRI findings. We also provide an initial assessment of potential clinical applications of these micro- and macrostructural features and corresponding normative ranges using selected cases with abnormal findings.

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