Abstract #4632

Delineation of language network maturation during infancy with multi-modal perfusion and functional MRI

Minhui Ouyang¹, Qinlin Yu¹, Huiying Kang², Yun Peng², Bo Hong³, and Hao Huang^1,4

¹Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, China, ³Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ⁴Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Human language capabilities are acquired during infancy. We hypothesized that language brain circuit emergence is supported by rapidly increasing regional cerebral blood flow (rCBF) to meet the metabolic demands. However, the spatiotemporal distribution of rCBF in language network during infancy is unknown. In this study, we acquired resting-state fMRI and pCASL perfusion MRI from 48 infants aged 0-24months for identifying language network and quantifying rCBF, respectively. Heterogeneous and significant age-dependent rCBF increases were found at specific functional regions of language network during this critical period.

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