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Abstract #4643

Greater reduction in functional connectivity strength in term neonates with congenital heart disease born earlier in gestation

Vincent Jerome Schmithorst1, Cecilia Lo2, Philip Adams2, Jodie Votava-Smith3, and Ashok Panigrahy1
1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2University of Pittsburgh, Pittsburgh, PA, United States, 3Children's Hospital of Los Angeles, Los Angeles, CA, United States

Functional connectivity strength (FCS) differences are investigated in term neonates with congenital heart disease (CHD) as compared to normal controls. In CHD neonates, FCS is reduced in default mode network (DMN), salience network (SN), and central executive network (CEN) regions. However, widespread positive post-conceptional age (PCA) at birth – X – CHD interactions were found, indicating this effect is more pronounced for CHD neonates born earlier in gestation, and that prolonged in utero exposure may be beneficial for development of brain functional connectivity. Negative correlations of nasal nitric oxide (nNO) and FCS were also found, suggesting a partly vascular etiology.

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