Abstract #4644

Altered brain activation during cognitive control in children with enuresis

Mengxing Wang¹, Xiangyu Zheng², Yue Liu¹, Jun Ma*^2,3, and Xiaoxia Du*⁴

¹College of Medical Imaging, Shanghai University of Medicine&Health Science, Shanghai, China, ²Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³MOE‑Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, China

This study was to investigate the potential disturbance in cognitive control in enuretic children using functional MRI. Two groups including enuretic and healthy children were scanned during a color-word Stroop task to evaluate their task performance and neural response. Compared to the healthy subjects, the children with enuresis showed stronger Stroop effect and increased activation for the incongruent > congruent condition contrast in the anterior cingulate and the precentral/postcentral gyri. Our results suggested that the enuretic children showed altered neural responses to conflict events and tended to compensate by greater activation to sustain normal cognitive control.

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