Abstract #4645

Fibers and Neuroanatomy in the Left Hemisphere Are More Associated with Neonatal Death and 2-Year Outcome after Hypoxic Ischemic Encephalopathy

Yanan Song^1,2, Sara V. Bates^3,4, Rebecca J. Weiss^3,4, Randy L. Gollub^4,5, Sheng He^1,4, Camilo Jaimes^4,6, Susan Sotardi^4,7, Yue Zhang^1,4, Tonghua Liu², P. Ellen Grant^1,4,6, and Yangming Ou^1,4,6

¹Fetal-Neonatal Neuroimaging Data Science Center, Boston Children's Hospital, Boston, MA, United States, ²Beijing University of Chinese Medicine, Beijing, China, ³Department of Pediatrics, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Department of Radiology, Boston Children's Hospital, Boston, MA, United States, ⁷Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Hypoxic ischemic encephalopathy affects ~5/1000 neonates and causes neonatal death and 2-year disability. Using neonatal MRI to predict neonatal and 2-year outcomes remains a key open question. However, expert scoring of neonatal MRI, the current norm, only focuses on a few key brain regions based on subjective clinical experience. We objectively and comprehensively examined the associations with neonatal and 2-year outcomes throughout the brain. Our new findings – many voxels, subregions and fibers that are not considered in expert scoring systems, with a left hemisphere dominance, were associated with outcomes – provide new knowledge for future individualized outcome prediction.

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