Meeting Banner
Abstract #4645

Fibers and Neuroanatomy in the Left Hemisphere Are More Associated with Neonatal Death and 2-Year Outcome after Hypoxic Ischemic Encephalopathy

Yanan Song1,2, Sara V. Bates3,4, Rebecca J. Weiss3,4, Randy L. Gollub4,5, Sheng He1,4, Camilo Jaimes4,6, Susan Sotardi4,7, Yue Zhang1,4, Tonghua Liu2, P. Ellen Grant1,4,6, and Yangming Ou1,4,6
1Fetal-Neonatal Neuroimaging Data Science Center, Boston Children's Hospital, Boston, MA, United States, 2Beijing University of Chinese Medicine, Beijing, China, 3Department of Pediatrics, Massachusetts General Hospital, Charlestown, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States, 6Department of Radiology, Boston Children's Hospital, Boston, MA, United States, 7Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Hypoxic ischemic encephalopathy affects ~5/1000 neonates and causes neonatal death and 2-year disability. Using neonatal MRI to predict neonatal and 2-year outcomes remains a key open question. However, expert scoring of neonatal MRI, the current norm, only focuses on a few key brain regions based on subjective clinical experience. We objectively and comprehensively examined the associations with neonatal and 2-year outcomes throughout the brain. Our new findings – many voxels, subregions and fibers that are not considered in expert scoring systems, with a left hemisphere dominance, were associated with outcomes – provide new knowledge for future individualized outcome prediction.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract