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Abstract #4650

Grey matter hypertrophy and atrophy in early-blind adolescents: a surface-based morphometric study

Zhifeng Zhou1, Xia Liu2, Long Qian3, Yang Fan4, Hai Li4, Gangqiang Hou2, Wentao Jiang2, and Hengguo Li5
1Radiology, Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, China, 2Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, China, 3GE Healthcare, Beijing, China, 4Beijing Intelligent Brain Cloud, Inc, Beijing, China, 5The First Affiliated Hospital of Jinan University, Guangzhou, China

Numerous studies have explored brain structural abnormalities in blind people. However, most of them were based on volumetric measures, using voxel-based morphology, or in a specific region of interest, which may conceal fine anatomic details in other features. This study investigated alterations in cortical morphologies (thickness, volume and surface area) in early-blind adolescents (EBAs) using a surface-based morphometric method. Our results showed that there was disuse atrophy, compensatory and experience-related neural plasticity in the cerebral cortex of EBAs due to the visual deprivation.

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