Abstract #4650

Grey matter hypertrophy and atrophy in early-blind adolescents: a surface-based morphometric study

Zhifeng Zhou¹, Xia Liu², Long Qian³, Yang Fan⁴, Hai Li⁴, Gangqiang Hou², Wentao Jiang², and Hengguo Li⁵

¹Radiology, Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, China, ²Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, China, ³GE Healthcare, Beijing, China, ⁴Beijing Intelligent Brain Cloud, Inc, Beijing, China, ⁵The First Affiliated Hospital of Jinan University, Guangzhou, China

Numerous studies have explored brain structural abnormalities in blind people. However, most of them were based on volumetric measures, using voxel-based morphology, or in a specific region of interest, which may conceal fine anatomic details in other features. This study investigated alterations in cortical morphologies (thickness, volume and surface area) in early-blind adolescents (EBAs) using a surface-based morphometric method. Our results showed that there was disuse atrophy, compensatory and experience-related neural plasticity in the cerebral cortex of EBAs due to the visual deprivation.

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