Abstract #4654

Characterization of cortical abnormalities in adolescents with first-episode drug-naïve major depressive disorder

Xinyue Hu¹, Ruohan Feng², Lianqing Zhang¹, Yang Li³, Xinyu Hu¹, Shi Tang¹, Yingxue Gao¹, Lihua Zhuo², Guoping Huang³, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China, ²Department of Radiology, the third hospital of Mianyang, Mianyang, China, Mianyang, China, ³Department of Psychiatry, the third hospital of Mianyang, Mianyang, China, Mianyang, China

The detailed information about neuroanatomical alterations in adolescents with first-episode drug-naïve major depressive disorder (MDD) is still unknown. We measured cortical thickness, surface area and volume in 35 MDD patients and 22 healthy controls (HC). The MDD group, compared to HCs, showed reduction in cortical volume of the right precentral gyrus. We also found that MDD severity significantly correlated with cortical abnormalities in a number of regions, primarily in frontal and parietal lobes. These regions are implicated in emotion processing whose abnormities will contribute to the affective and cognitive dysfunction in adolescents with MDD.

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