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Abstract #4655

Sex Differences across Brain Regions in Neonates

Jianliang Gao1, Ahmed Fetit1, John Cupitt1, Jonathan Passerat-Palmbach1, Amir M Y F M Alansary1, Antonios Makropoulos1, Emma Robinson2, Sean Fitzgibbon3, Matteo Bastiani3,4, Nickolas Harper2, Lucilio Cordero Grande2, Anthony N Price2, Eugene Duff3, Steve Smith3, Joseph V Hajnal2, David Edwards2, and Daniel Rueckert1
1BioMedIA, Department of Computing, Imperial College London, London, United Kingdom, 2Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

We present for the first time a large cohort of neonatal brain MR images were acquired. Based on 505 subjects' MRI brain imaging data were acquired as part of the developing Human Connectome Project (dHCP) , we investigated the differences of 92 brain regions and brain volume without and with normalization of the volumes. Using multivariate analysis and adaptive step-down false discovery rate (FDR) control methods to examine term born neonates, we found 90 out of 92 regions and the brain volume statistically significant between sexes. But selected data normalization methods also suggested less statistical significance in neonatal brain regions.

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