Abstract #4662

Left inferior fronto-occipital fasciculus is key anatomical location of cognitive delay in preterm infants with mild white matter injury

Miaomiao Wang¹, Xianjun Li¹, Congcong Liu¹, Xiaoyu Wang¹, Yannan Cheng¹, Huifang Zhao¹, Xingxing Tao¹, Fan Wu¹, Yuli Zhang¹, Mengxuan Li¹, Cong Tian¹, Peiyao Chen¹, Chao Jin¹, XiaoCheng Wei², and Jian Yang³

¹Department of Diagnostic Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, ²MR Research China, GE Healthcare, Beijing, China, ³Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

Punctate white matter lesions (PWMLs) are common in the preterm. The mild PWMLs may result in cognitive impairments and lesion location is closely associated with neurodevelopmental outcomes. Accurate assessment of lesions location on qualitative MRI is difficult; therefore, this study aims to investigate the lesion-symptom relationship between locations of mild PWMLs and cognitive functioning in preterm infants at a corrected age of 3-6 months by diffusion tensor imaging. Lesion volume on IFOF_L is significantly larger in the cognitive delayed group than those in the normal group, and this is an independent factor (OR: 1.26) associated with the adverse cognitive development.

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