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Abstract #4662

Left inferior fronto-occipital fasciculus is key anatomical location of cognitive delay in preterm infants with mild white matter injury

Miaomiao Wang1, Xianjun Li1, Congcong Liu1, Xiaoyu Wang1, Yannan Cheng1, Huifang Zhao1, Xingxing Tao1, Fan Wu1, Yuli Zhang1, Mengxuan Li1, Cong Tian1, Peiyao Chen1, Chao Jin1, XiaoCheng Wei2, and Jian Yang3
1Department of Diagnostic Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, 2MR Research China, GE Healthcare, Beijing, China, 3Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

Punctate white matter lesions (PWMLs) are common in the preterm. The mild PWMLs may result in cognitive impairments and lesion location is closely associated with neurodevelopmental outcomes. Accurate assessment of lesions location on qualitative MRI is difficult; therefore, this study aims to investigate the lesion-symptom relationship between locations of mild PWMLs and cognitive functioning in preterm infants at a corrected age of 3-6 months by diffusion tensor imaging. Lesion volume on IFOF_L is significantly larger in the cognitive delayed group than those in the normal group, and this is an independent factor (OR: 1.26) associated with the adverse cognitive development.

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