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Abstract #4664

Mahalanobis Distance Tractometry (MaD-Tract) for Multivariate Analyses

Jose Manuel Guerrero-Gonzalez1, Peter Ferrazzano2, and Andrew Alexander1
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Pediatrics, University of Wisconsin - Madison, Madison, WI, United States

We present a multi-parameter tract profiling approach which allows for comparing diffusion imaging quantities between a single subject and a reference group along specific white matter path ways using the Mahalanobis distance (MaD). Implementation of MaD-Tract on a pediatric TBI-affected brain revealed several deviant tract segments in terms of elevated MaD values along multiple tracts compared to a group of healthy individuals.

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