Abstract #4665

Early developmental differences of white matter tracts in preterm infants with brain injury

Tao Guo¹, Dawn Gano², Donna Ferriero², James barkovich¹, and Duan Xu¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, ²Department of Neurology and Pediatrics, University of California, San Francisco, CA, United States

We detected early developmental differences of white matter tracts in preterm infants with brain injury (BI). Nineteen preterm infants underwent two MRI scans. Microstructural development was analyzed combining conventional diffusion parameters and advanced NODDI parameters . We found BI preterm infants showed higher ODI in internal capsule, which was positively correlated with brain injuries severity; during the longitudinal period, most of the tracts in non-injured preterm infants had increased FA and Vic, decreased MD and ODI, while in BI preterm infants, only a few tracts developed. This study indicated white matter development was different in preterm infants with and without BI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.