Abstract #4667

Relationships between myelin development and neurodevelopmental outcomes in very preterm and typically developing children

Deanne K Thompson^1,2,3,4, Joseph YM Yang^2,3,5,6, Jian Chen², Claire E Kelly^1,2, Chris L Adamson², Bonnie Alexander^1,2, Lillian G Matthews⁷, Katherine J Lee^1,3,8, Rod W Hunt^1,3,9, Jeanie LY Cheong^1,10,11, Megan Spencer-Smith^1,12, Marc L Seal^2,3, Terrie E Inder^1,7, Lex W Doyle^1,3,10,11, and Peter J Anderson^1,12

¹Victorian Infant Brain Studies, Murdoch Children's Research Institute, Parkville, Australia, ²Developmental Imaging, Murdoch Children's Research Institute, Parkville, Australia, ³Department of Paediatrics, University of Melbourne, Parkville, Australia, ⁴Florey Institute of Neuroscience and Mental Health, Parkville, Australia, ⁵Neuroscience Research, Murdoch Children’s Research Institute, Parkville, Australia, ⁶Department of Neurosurgery, the Royal Children’s Hospital, Parkville, Australia, ⁷Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁸Clinical Epidemiology & Biostatistics Unit, Murdoch Children’s Research Institute, Parkville, Australia, ⁹Neonatal Medicine, Royal Children’s Hospital, Parkville, Australia, ¹⁰Royal Women's Hospital, Parkville, Australia, ¹¹Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia, ¹²Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Australia

Children born very preterm have altered myelination compared with full-term controls, but whether the T1-T2 ratio is a sensitive measure for understanding neurodevelopmental functioning remains unknown. This study found that the T1-T2 ratio trajectory between 7 and 13 years of age in the uncinate fasciculus was related to IQ scores, and 13-year T1-T2 ratios in almost all white matter regions were associated with motor functioning in both birth groups. Myelin development assessed using the T1-T2 ratio appears to be sensitive to predicting some neurodevelopmental outcomes.

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