Abstract #4668

Fixel-based analysis of white matter differences between patients with cerebral palsy and typically developing children

Chih-Chien Tsai¹, Chia-Ling Chen^2,3, Yao-Liang Chen⁴, Jur-Shan Cheng⁵, Sung-han Lin⁶, and Jiun-Jie Wang^1,6,7

¹Healthy Aging Research Center, Chang-Gung University, TaoYuan, Taiwan, ²Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, TaoYuan, Taiwan, ³Graduate Institute of Early Intervention, College of Medicine, Chang Gung University, TaoYuan, Taiwan, ⁴Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan, ⁵Clinical Informatics and Medical Statistics Research Center, Chang-Gung University, TaoYuan, Taiwan, ⁶Department of Medical Imaging and Radiological Sciences, Chang Gung University, TaoYuan, Taiwan, ⁷Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, TaoYuan, Taiwan

Disruption to white matter pathways is an important contributor to the pathogenesis of cerebral palsy but fail to delineate white matter tracts with lesions precisely with conventional magnetic resonance imaging. Fixel-based analysis, which has recently emerged as a useful fiber-specific tool for examining white matter structure, was used in this study. Reductions of fixel-based metrics in patients with cerebral palsy are represented in the corpus callosum, superior/posterior thalamic radiation, optic radiation, superior longitudinal fasciculus, and cingulum with corresponding direction of fiber tract. By using fixel-based analysis, this study described the white matter differences during development in patients with cerebral palsy.

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