Abstract #4672

Magnitude and timing of major white matter along-tract maturation with NODDI

Kirsten M Lynch¹, Ryan P Cabeen², Kristi A Clark², and Arthur W Toga²

¹Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Mark and Mary Stevens Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States

White matter maturation is a heterogeneous phenomenon that can be probed by biophysical models. The purpose of this study was to characterize the development of white matter tracts with NODDI from infancy through adolescence. To probe the regional nature of white matter development, we use an along-tract approach to enable more fine-grained analysis. White matter tracts showed exponential age-related changes in NDI with spatially distinct maturational patterns. Our along-tract analyses elucidate hemispheric asymmetries within tracts which may be reflective of their functional specialization. Together, these results help to disentangle the processes that define the trajectory of white matter maturation.

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