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Abstract #4673

Early Changes in Diffusion Tensor Metrics between Different Final Damage Outcomes after Experimental Neonatal Hypoxic Ischemia

Yu-Chieh Jill Kao1,2,3, Chia-Feng Lu4, Bao-Yu Hsieh5, Chao-Ching Huang6, and Cheng-Yu Chen1,2,3,7
1Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, 4Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 5Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 6Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 7Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

Changes in diffusion tensor metrics within 6 h after hypoxic ischemia (HI) in different brain regions in neonatal rats is associated with the final lesion severity after hypoxic ischemia. We also demonstrated that the early changes within 6 h after HI may also correlate to the alteration in ultra-structure in the neurons and axons following the injury.

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