Abstract #4673

Early Changes in Diffusion Tensor Metrics between Different Final Damage Outcomes after Experimental Neonatal Hypoxic Ischemia

Yu-Chieh Jill Kao^1,2,3, Chia-Feng Lu⁴, Bao-Yu Hsieh⁵, Chao-Ching Huang⁶, and Cheng-Yu Chen^1,2,3,7

¹Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ⁴Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁵Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ⁶Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁷Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan

Changes in diffusion tensor metrics within 6 h after hypoxic ischemia (HI) in different brain regions in neonatal rats is associated with the final lesion severity after hypoxic ischemia. We also demonstrated that the early changes within 6 h after HI may also correlate to the alteration in ultra-structure in the neurons and axons following the injury.

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