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Abstract #4674

Fixel-based analysis reveals white matter changes following balance training in young brain injured patients: A longitudinal study

Xiaoyun Liang1,2, Chun-Hung Yeh2, Juan F Domínguez D1, Govinda Poudel1, and Karen Caeyenberghs1
1Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Australia, 2Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

Traumatic brain injury (TBI) is one of the leading causes of death and disability in children and adolescents. Young TBI patients suffer from gross motor deficits, such as postural control deficits, which can severely compromise their daily life activities. Training programs have shown behavioral improvement; evidence of changes in WM morphology, however, has not been clear. We employ a fixel-based analysis (FBA) to investigate whether balance training results in significant changes of WM organization across whole brain in young TBI patients over time. Our results have shown that balance training induced signigicant macrostructural white matter changes (i.e. log-FC & FDC).

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