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Abstract #4678

Quantification of brain glycine in an infant with nonketotic hyperglycemia: a serial proton magnetic resonance spectroscopy study

Moyoko Tomiyasu1,2, Jun Shibasaki3, Yasuhiro Kawai4, Tatsuya Higashi1, Takayuki Obata1, and Noriko Aida1,2
1Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Radiology, Kanagawa Children's Medical Center, Yokohama, Japan, 3Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan, 4Neurology, Kanagawa Children's Medical Center, Yokohama, Japan

We serially examined in vivo brain glycine levels in an infant with nonketotic hyperglycemia (NKH) using single-voxel proton magnetic resonance spectroscopy (MRS) with different point-resolved spectroscopic localization sequence echo times (TEs). The time-course changes of brain glycine obtained with TEs of 60 and 270 ms corresponded with glycine concentrations in cerebrospinal fluid and with the clinical condition of the infant. By appropriately combing a pulse sequence and acquisition parameters, proton MRS can evaluate brain glycine levels to help diagnose NKH.

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