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Abstract #4679

Pediatric acute mTBI study of GABA concentration in posterior cingulate cortex

Andrei Manzhurtsev1,2, Maxim Ublinskiy1,3, Petr Menshchikov1, Alexey Yakovlev2,4, Olga Bozhko3, Tolib Akhadov3, and Natalia Semenova1,3,4
1Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russian Federation, 3Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, 4Semenov Institute of Chemical Physics of the Russian Academy of Science, Moscow, Russian Federation

This is the first measurement of pure GABA concentration in the PCC of children with mild TBI in the acute phase. MEGA-PRESS pulse sequence was used in order to obtain GABA signal not contaminated by macromolecules. The result obtained disagrees with the previous study, where [GABA] was increased in the anterior cingulate cortex of children with mTBI when comparing to healthy controls. The findings may signify that ACC is more sensitive to mTBI than PCC.

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