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Abstract #4702

DKI-Based Mahalanobis Distance Assessing Alterations of Brain White Matter in Infants With Benign Enlargement of Subarachnoid Space 

Congcong Liu1, Xianjun Li1, Miaomiao Wang1, Chao Jin1, Fan wu1, Cong Tian1, Mengxuan Li1, Xiaocheng Wei2, and Jian Yang1
1Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, 2MR Research China, GE Healthcare, Xi'an, China

Some infants with BESS were accompanied with mildly motor and language delay. White matter (WM) development is important to neurodevelopmen, but relationships between BESS and WM maturation are not very clear. Mahalanobis distance is a feasible multivariate approach to evaluate white matter maturation. This study aims to quantitative assess the WM microstructures of in infant with BESS aged 4-6 months via DKI-based Mahalanobis distance. Larger Mahalanobis distance was found in infants with BESS among most WM tracts. All these changes of WM tracts suggested underlying alterations and prematuration of white matter. It may provide additional information for the neurodevelopment outcomes.

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