Some infants with BESS were accompanied with mildly motor and language delay. White matter (WM) development is important to neurodevelopmen, but relationships between BESS and WM maturation are not very clear. Mahalanobis distance is a feasible multivariate approach to evaluate white matter maturation. This study aims to quantitative assess the WM microstructures of in infant with BESS aged 4-6 months via DKI-based Mahalanobis distance. Larger Mahalanobis distance was found in infants with BESS among most WM tracts. All these changes of WM tracts suggested underlying alterations and prematuration of white matter. It may provide additional information for the neurodevelopment outcomes.