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Abstract #4707

Longitudinal voxel-based analysis in Alzheimer’s disease transgenic marmosets

Fumiko Seki1,2, Seiji Shiozawa2, Sho Yoshimatsu2, Yuji Komaki1, Marin Nishio3, Erika Sasaki1, and Hideyuki Okano2
1Central Institute for Experimental Animals, Kawasaki, Japan, 2Department of Physiology, Keio University School of Medicine, Tokyo, Japan, 3Department of Radiological Science, Tokyo Metropolitan University, Tokyo, Japan

This study investigated whether MRI could detect brain abnormalities in transgenic marmoset models of Alzheimer’s disease (AD). Magnetization transfer (MT) contrast-MRI have a potential to detect the presence of amyloid plaques, which could be present in the early stage of the diseases. Voxel-based analysis was conducted to explore whether any difference existed between AD models and healthy marmosets (young-to-middle-aged adults). Significant increase of MT-ratios imaging was observed in posterior cingulate cortex whereas decrease was observed in unilateral inferior temporal cortex. This result supported MT-imaging was sensitive to early abnormalities. Continuous evaluation until old age is worthwhile to be clinically relevant.

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