This study investigated whether MRI could detect brain abnormalities in transgenic marmoset models of Alzheimer’s disease (AD). Magnetization transfer (MT) contrast-MRI have a potential to detect the presence of amyloid plaques, which could be present in the early stage of the diseases. Voxel-based analysis was conducted to explore whether any difference existed between AD models and healthy marmosets (young-to-middle-aged adults). Significant increase of MT-ratios imaging was observed in posterior cingulate cortex whereas decrease was observed in unilateral inferior temporal cortex. This result supported MT-imaging was sensitive to early abnormalities. Continuous evaluation until old age is worthwhile to be clinically relevant.