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Abstract #4706

A Rabbit Model of Intracranial Atherosclerotic Disease for Pathologic Validation of Vessel Wall MRI

J Scott McNally1, Adam de Havenon1, Seong-Eun Kim1, Chuanzhuo Wang2, Matthew Zabriskie1, Dennis Parker1, Hediyeh Baradaran1, and Matthew David Alexander3
1University of Utah, Salt Lake City, UT, United States, 2Shengjing Hospital of China Medical University, Shenyang, China, 3Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

Two rabbit model types (Watanabe Heritable Hyperlipidemic and Apolipoprotien E knockout) were studied with vessel wall MRI (vwMRI) and confirmatory histopathological analysis to evaluate for presence of intracranial atherosclerosis (ICAD). Disease was reliably produced in both rabbit types. Sensitivity and specificity of vwMRI for detection of ICAD were 89.5% and 91.9%, respectively. When excluding mild cases to assess accuracy vwMRI for detecting moderate to severe ICAD lesions, sensitivity improved to 100% with unchanged specificity.

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