Abstract #4705

3D High Resolution T1 and T2 Mapping at Ultrahigh Fields Using Magnetic Resonance Fingerprinting

Yuning Gu¹, Yun Wu², Hongyi Yang², Yong Chen³, Jesse I. Hamilton⁴, Nicole Seiberlich^3,4, Charlie Androjna⁵, Kai Zhong², and Xin Yu^1,3,6

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China, ³Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ⁵Cleveland Clinic Pre-Clinical Magnetic Resonance Imaging Center, Cleveland Clinic Foundation, Cleveland, OH, United States, ⁶Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

This study demonstrates the development of a 3D T₂-prepared MRF sequence, in combination with a stack-of-spirals trajectory, for simultaneous T₁ and T₂ mapping of an ex vivo macaque monkey (Macaca mulatta) brain with a voxel size of 0.35x0.35x1 mm³. Retrospective evaluation of the undersampling accuracy showed that, for an undersampling rate of up to 16, the normalized root mean square error was within 6% and 15% in T₁ and T₂ mapping, respectively. These results suggest that 3D simultaneous T₁ and T₂ mapping can be in <30 min with unprecedented spatial resolution.

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