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Abstract #4704

An In-vivo Assessment of Regional Brain Temperature during Whole-body Cooling for Neonatal Encephalopathy

Tai-Wei Wu1, Jessica Lee Wisnowski1, Rachel Chapman1, Marvin D Nelson2, Benita Tamrazi2, and Stefan Bluml2,3
1Neonatology, Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, 2Radiology, Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, 3Rudi Schulte Research Institute, Santa Barbara, CA, United States

Regional brain temperatures in newborns hypoxic-ischemic encephalopathy (HIE) were measured during whole-body hypothermia (TH) to test the hypothesis that brain temperature profile is non-homogenous and is related to pattern or severity of brain injury. We found that whole body hypothermia was effective in cooling deep brain structures, while superficial structures were warmer and significantly higher than rectal temperature. It was also observed that infants with more severe brain injury exhibited higher brain temperatures without regional temperature differences.

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