It remains challenging to acquire 3D isotropic high resolution T1 mapping in in vivo MRI experiments. The increase of T1 mapping resolution and coverage are typically limited by the scan time. The purpose of this study is to investigate the feasibility of estimate 3D isotropic high resolution T1 mapping using the variable flip angle (VFA) method1 and 3D-UTE-GRASP sequence2 for small animal imaging at 7T within 3 minutes.
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