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Abstract #4710

Extracellular Volume Fraction (ECV) of Liver Tumors: Mapping of VX2 Tumors in Rabbits before and after Therapy.

Dana C Peters1, Jonatan C. Ferm1, Lynn Savic1, Steffen Huber1, John Walsh1, Daniel Coman1, Fahmeed Hyder1, Mingde Lin1, James S Duncan1, Douglas Rothman1, Albert J Sinuas1, Julius Chapiro1, and R. Todd Constable1
1Yale University, New Haven, CT, United States

In this work, we studied a VX2 tumor in rabbits, which provides a model for hepatocellular carcinoma. The rabbits were imaged with T1 mapping (pre- and post-contrast), which was used to generate extracellular volume fraction (ECV) maps. The average ECV for normal liver and tumor was 20 +/-11 % and 18 +/- 7%, respectively. One week after TACE, tumor ECVs fell to zero, but recovered slightly at two weeks, while normal liver ECV values changed variably after TACE. This preliminary study shows that ECV mapping can depict the highly heterogeneous tumor morphology.

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