In this work, we studied a VX2 tumor in rabbits, which provides a model for hepatocellular carcinoma. The rabbits were imaged with T1 mapping (pre- and post-contrast), which was used to generate extracellular volume fraction (ECV) maps. The average ECV for normal liver and tumor was 20 +/-11 % and 18 +/- 7%, respectively. One week after TACE, tumor ECVs fell to zero, but recovered slightly at two weeks, while normal liver ECV values changed variably after TACE. This preliminary study shows that ECV mapping can depict the highly heterogeneous tumor morphology.
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