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Abstract #4711

Influence of formalin-based fixatives on the MR properties of whole post-mortem pig brains

Azadeh Nazemorroaya1, Ali Aghaeifar1, Hildegard Schulz1, Thomas Shiozawa-Bayer2, Bernhard Hirt2, Klaus Scheffler3,4, and Gisela Hagberg4,5
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Clinical Anatomy, University of Tübingen, Tuebingen, Germany, 3High Field Magnetic Resonance,, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Biomedical Magnetic Resonance, University of Tübingen, Tuebingen, Germany, 5High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Post-mortem brain MRI can yield valuable information. However, tissue preservation and MR-compatibility of fixation agents are challenging. Here we investigated the effect of four MR-compatible formalin-based fixatives on the MR properties of pig brains at several timepoints after start of fixation up to one month. The inclusion agents known to improve the dielectric properties of the fixatives lead to greater R2* difference between GM-WM than conventional fixatives. Vice versa these agents lead to a decrease in T1 contrast.

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