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Abstract #4715

Characterization of cerebral metabolism in prodromal stage of disease progression in rat model of Alzheimer's disease

Illsung Joo1, Margaret Koletar1, Wilfred W Lam1, Wendy Oakden1, Greg J Stanisz1, JoAnne McLaurin1, and Bojana Stefanovic1
1Physical Sciences, University of Toronto, Toronto, ON, Canada

Alzheimer’s disease (AD) has complex underlying mechanism associated with progressive decline in multiple aspects of brain functions. This work aims to characterize cerebral metabolic alteration in presymptomatic AD in terms of glucose uptake and β-hydroxybutyrate (βHB) concentration in hippocampus (HC) and entorhinal cortex (EC) of rat model of AD using MR imaging and spectroscopic techniques. Glucose uptake was significantly reduced in HC and trending toward decrease in EC with signs of elevated HC βHB concentration in AD transgenic rat when compared to metabolic markers in healthy subjects, demonstrating that metabolic alteration precedes onset of AD cognitive symptoms.

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