Abstract #4714

Comparison of metabolic fluxes in the mouse dorsal hippocampus and hypothalamus using indirect 1H-[13C] MRS upon [1,6-13C2] glucose infusion

Antoine Cherix¹, Bernard Lanz¹, and Hongxia Lei²

¹Laboratory for Functional and Metabolic, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

With increased interests in understanding the hippocampal regulation of hypothalamic-pituitary-adrenocortical (HPA) axis, this study shows for the first time an in vivo comparison of metabolic fluxes in the mouse dorsal hippocampus and hypothalamus using indirect ¹H-[¹³C] MRS upon [1,6-¹³C₂] glucose infusion at 14.1T. This study provides foundation for investigating relevant evidence to the underlying mechanism of hippocampal regulation of HPA axis.

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