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Abstract #4713

Deuterium Metabolic Imaging (DMI) of glucose metabolism in mouse brain.

Henk M. De Feyter1, Monique A. Thomas1, Peter B. Brown1, Akshay Khunte1, and Robin A. de Graaf1
1Dept. of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

Deuterium Metabolic Imaging (DMI) is a novel approach providing high spatial resolution 3D metabolic data by combining 2H MRSI with administration of 2H-labeled substrates (1). Mapping of brain glucose metabolism has so far been focused on human and rat. Here we report the implementation of DMI for mapping of glucose metabolism in mouse brain. We described the dedicated radiofrequency coil, explore how different glucose administration approaches affect SNR, and illustrate mapping of glucose metabolism in a mouse model of glioblastoma.

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