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Abstract #4717

Microstructures and metabolites during HIV-1 infection of humanized microglia mice revealed by MRI and MRS

YUTONG LIU1, Saumi Mathews2, Ed Makarov2, Lili Guo2, Mariano Uberti1, Balasrinivasa Sajja1, Larisa Poluektova2, Howard Gendelman2, and Santhi Gorantla2
1Radiology, University of Nebraska Medical Center, Omaha, NE 68198, NE, United States, 2Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, NE, United States

In this study, we performed DTI and MRS on a newly created mouse model of brain HIV infection. MRS results showed neuronal damage on hippocampus, and DTI showed diffuse neuroinflammation caused by HIV infection. White matter changes was also observed using DTI.

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