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Abstract #4718

Microvascular Architecture Changes in the Brain of an Alzheimer’s disease Mouse

Suk-Ki Chang1, JeongYeong Kim2, DongKyu Lee3, Chang Hyun Yoo4, Jin San Lee5, Hak Young Rhee6, Chang-Woo Ryu7, HyungJoon Cho3, and Geon-Ho Jahng7
1Radiology, Hallym University medical center, Hwasung, Kyung-gi-Do, Republic of Korea, 2Department of physics, Kyung Hee University, Seoul, Republic of Korea, 3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 4Department of Physics and Research Institute for Basic Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea, 5Department of Neurology, Kyung Hee University Hospital, Seoul, Republic of Korea, 6Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea, 7Department of Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea

To characterize and evaluate microvascular architectures presented by brain microvascular indices obtained with a 7T animal MRI system in the transgenic (Tg) AD-model mice and the non-Tg mice using monocrystalline iron oxide nanoparticle (MION) contrast agent, seven non-transgenic (Tg) mice and ten 5xFAD Tg mice were scanned to measure the R2 and R2* relaxation rates before and after injection of MION contrast agent. ΔR2, ΔR2*, BVf, mVD, VSI, and MvWI were greater in the Tg mouse group than in the non-Tg mouse group. ADC and mean vessel density Q were not significantly different between the two groups.

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