Abstract #4718

Microvascular Architecture Changes in the Brain of an Alzheimer’s disease Mouse

Suk-Ki Chang¹, JeongYeong Kim², DongKyu Lee³, Chang Hyun Yoo⁴, Jin San Lee⁵, Hak Young Rhee⁶, Chang-Woo Ryu⁷, HyungJoon Cho³, and Geon-Ho Jahng⁷

¹Radiology, Hallym University medical center, Hwasung, Kyung-gi-Do, Republic of Korea, ²Department of physics, Kyung Hee University, Seoul, Republic of Korea, ³Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, ⁴Department of Physics and Research Institute for Basic Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea, ⁵Department of Neurology, Kyung Hee University Hospital, Seoul, Republic of Korea, ⁶Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea, ⁷Department of Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea

To characterize and evaluate microvascular architectures presented by brain microvascular indices obtained with a 7T animal MRI system in the transgenic (Tg) AD-model mice and the non-Tg mice using monocrystalline iron oxide nanoparticle (MION) contrast agent, seven non-transgenic (Tg) mice and ten 5xFAD Tg mice were scanned to measure the R2 and R2* relaxation rates before and after injection of MION contrast agent. ΔR2, ΔR2*, BVf, mVD, VSI, and MvWI were greater in the Tg mouse group than in the non-Tg mouse group. ADC and mean vessel density Q were not significantly different between the two groups.

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