Abstract #4719

DTI-based Hemispheric Differences in Female 3xTgAD Mouse Model

David Hike^1,2, Taylor Ariko^1,2, Alina Stimmell³, Aaron Wilber³, and Samuel Colles Grant^1,2

¹Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ²CIMAR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ³Psychology, Florida State University, Tallahassee, FL, United States

This study utilizes DTI and graph theory as a method for early detection of structural changes inconnectivity related to Alzheimer’s Disease. As a function of phenotype and age, DTI analysis was implemented on 3xTgAD female mouse brains and wild type controls at 11.75-T. Current hemisphere dependent data shows differences between hemispheres within the age and phenotype for the parameters observed.

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