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Abstract #4719

DTI-based Hemispheric Differences in Female 3xTgAD Mouse Model

David Hike1,2, Taylor Ariko1,2, Alina Stimmell3, Aaron Wilber3, and Samuel Colles Grant1,2
1Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, 2CIMAR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, 3Psychology, Florida State University, Tallahassee, FL, United States

This study utilizes DTI and graph theory as a method for early detection of structural changes inconnectivity related to Alzheimer’s Disease. As a function of phenotype and age, DTI analysis was implemented on 3xTgAD female mouse brains and wild type controls at 11.75-T. Current hemisphere dependent data shows differences between hemispheres within the age and phenotype for the parameters observed.

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