Abstract #4726

Lung and kidney metabolism altered by cancer-induced cachexia

Raj Kumar Sharma¹, Santosh K. Bharti¹, Paul T Winnard¹, Marie-France Penet^1,2, and Zaver M. Bhujwalla^1,2,3

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

To understand the impact of pancreatic cancers on body organs within the context of cancer induced cachexia we have, in ongoing studies, characterized the metabolism of organs in tumor bearing mice. Cancer-induced cachexia occurs in 80% of pancreatic ductal adenocarcinoma (PDAC) patients. Here we present data demonstrating the significant impact of cachexia-inducing Pa04C PDAC xenografts compared to non-cachexia inducing Panc1 xenografts and normal mice on kidney and lung metabolites as identified by 1H MRS of tissue extracts. These metabolic changes may contribute to increased morbidity and poor quality of life but equally may present novel targets for intervention.

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